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How to use Great Runes
First, visit the Divine Tower in the region where you obtained the Great Rune (e.g. for Godrick, Tower of Limegrave). Restore power to your Great Rune. Rest at a site of Grace and equip from the Great Runes menu item. Use a Rune Arc to receive the bonus. Effects expire after death. Earn Rune Arcs from co-op play or purchase from Twin Maiden Husks at Roundtable Hold (Table of Lost Grace).