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Use Golden Runes when you're desperate
If you're very close to leveling up or can barely afford an item, don't forget about the Golden Runes in your inventory. These Runes are not lost when you die and you don't have to retrieve them. Make use of them at your convenience, especially if you're worried about dying. They each have a different value so make note of the number (e.g. Golden Rune [1]), the lower the less Runes are given.